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Want to Know How to Travel from Orlando to Gainesville?

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Whether you hope to travel from Orlando to Gainesville by bus or by car, we have the best tips to help you get here quickly, safely, and comfortably! Choose your method of transportation, check out our recommendations, and start packing your bags to visit us at Sweetwater Branch Inn! And, if you want to learn about everything you can do in the area while staying here, make sure you get our free Vacation Guide. We have suggestions on the best restaurants, nightlife, events, shows, and outdoor activities to explore during your trip. While you’re sitting on the bus or in the car, scroll through it and plan out your entire weekend.


Plan your Stay with a Vacation Guide


There are a Few Ways to Travel From Orlando to Gainesville:

Travel by Bus

Instead of browsing endlessly for the perfect bus service, we know these bus companies will provide you with the most comfortable, 1-hour and 43-minute drive:

Greyhound bus service is one of the most reliable companies to use for your weekend getaway from Orlando! Their ticket prices range from as low as $18 to $35 per person. Their busses also offer power outlets and free wifi for you to enjoy during the short trip!

Redcoach is another great bus service you can use. They also provide wifi and power outlets, and their ticket prices are pretty comparable to the other bus companies in the area!

When you arrive at Sweetwater Branch Inn, it’s no problem if you don’t have a car! Request to use our bike rentals during your stay so you can explore everything you want to see in the area. We’re located just blocks away from the heart of downtown Gainesville, FL, so it takes no effort to ride straight into the city!

Travel by Car

A road trip to Gainsville, FL, from Orlando, is a pretty easy drive. There are only three main directions you need to know to get to the city:

Get on FL-408 West

Follow Florida’s Turnpike until you merge onto I-75 North.

Finally, take exit 374, which leads you down US-441 and straight into Gainesville!

If you want to make a scenic stop, the quaint town of Micanopy, Florida, is located almost immediately off of exit 374. You’ll go right by it! If you have time, we recommend spending an hour or two meandering through this town that seems frozen in time.

Where to Stay in Gainesville, FLview of the window seat in isadoras room

So you’ve planned how to travel from Orlando to Gainesville, but have you thought about where you’re going to stay for the weekend? Enjoy a unique stay with us here at Sweetwater Branch Inn. Our Victorian-style home is filled with plenty of rooms with more character and charm than you’d find at your usual chain hotel. Check out Isadora’s Room, with it’s artfully crafted cathedral ceilings, the large window seat next to gorgeous stained glass, and a cozy queen bed.

Do something different: visit the Inn!

Reserve a Unique Stay